👤 whose
Whose work first identified the SRY gene as the testis-determining factor?
Human BiologyGenetics
Quick Answer
Robin Lovell-Badge, Peter Goodfellow, and colleagues identified SRY as the key gene on the Y chromosome in the early 1990s. It was a major breakthrough in sex-determination biology.
The Full Story
In 1990, researchers including Robin Lovell-Badge and Peter Goodfellow showed that the SRY gene on the Y chromosome triggers male development by initiating testis formation. This solved a long-standing question about how the Y chromosome directs sex determination in mammals. The discovery demonstrated that a single gene can act as a developmental switch. It also helped explain certain differences in sex development when the gene or its pathway is altered.
Key Facts
1.SRY was identified as the key sex-determining gene in 1990
2.It sits on the Y chromosome
3.It activates the pathway toward testis development
YouTube Angle
Suggested video title for this topic:
"The one gene that flips embryonic sex development on"