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Whose research first identified X-chromosome inactivation in mammals?
Human BiologyGenetics
Quick Answer
Mary Lyon proposed X-chromosome inactivation in 1961. The process is now often called lyonization.
The Full Story
Mary Lyon proposed in 1961 that one of the two X chromosomes in female mammals becomes largely inactivated early in development. This balances gene dosage between XX females and XY males. The inactive X can be seen as a condensed Barr body in many cells. Lyon’s idea became one of the most influential concepts in developmental genetics.
Key Facts
1.Lyon’s proposal was published in 1961
2.X-inactivation helps balance gene dosage
3.The inactive X is often visible as a Barr body
YouTube Angle
Suggested video title for this topic:
"Why female mammals silence one X chromosome"