❓ why

Why do blood types matter in transfusions?

Human BiologyBlood

Quick Answer

Blood types matter because the immune system can attack red blood cells with unfamiliar surface markers. Matching ABO and Rh types helps prevent dangerous reactions.

The Full Story

Red blood cells carry antigens on their surfaces, including ABO group markers and the Rh factor. If a person receives incompatible blood, antibodies may attack the donor cells, causing them to clump or break apart. The ABO system was discovered by Karl Landsteiner in 1901, and the Rh factor became important in transfusion medicine in the 20th century. Careful blood typing is one of the reasons modern transfusions are much safer than they once were.

Key Facts

1.ABO blood groups were discovered by Karl Landsteiner in 1901
2.Rh compatibility also matters in transfusions
3.Incompatible blood can trigger immune destruction of red cells

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