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Which human gene is most strongly associated with Alzheimer’s disease risk?
Quick Answer
APOE is the best-known risk gene for late-onset Alzheimer’s disease. The APOE ε4 variant raises risk more than the other common forms.
The Full Story
The APOE gene helps transport cholesterol and other lipids in the brain and body. Of its common forms, the ε4 variant is associated with a higher risk of late-onset Alzheimer’s disease, while ε2 is generally linked to lower risk. APOE is a risk factor, not a certainty: many people with ε4 never develop Alzheimer’s, and many patients do not have ε4. Research on APOE has been central to understanding how genetics influences brain aging.
Key Facts
1.APOE has common variants called ε2, ε3, and ε4
2.ε4 increases risk of late-onset Alzheimer’s disease
3.It is a risk gene, not a guaranteed cause
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Suggested video title for this topic:
"One gene can shift your odds for Alzheimer’s disease."
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