Why Do Wounds Itch When Healing?

When skin is damaged, the body launches an inflammatory response. White blood cells release histamine, which increases blood flow to the area and triggers nearby nerve fibres, producing itchiness. As healing progresses, new collagen fibres are laid down and the wound contracts, mechanically stimulating nerve endings. Additionally, new skin cells migrating across the wound bed activate itch-sensing C-fibres. The itch is a sign of active repair, but scratching can reopen the wound and introduce bacteria, which is why the urge is best resisted.