When was the first successful human pancreas transplant performed?

The first successful human pancreas transplant was carried out in 1966 in Minneapolis by surgeons including Richard Lillehei and William Kelly. The procedure was aimed at treating severe diabetes by replacing insulin-producing tissue. Early pancreas transplantation was difficult, but it eventually became an important option for selected patients, especially those receiving kidney transplants as well. It helped prove that endocrine replacement by organ transplant was possible.