⏰ when
When was the first human gene linked to a specific disease?
Quick Answer
A major early example came in 1983, when the Huntington's disease gene was linked to chromosome 4. This was one of the first disease genes mapped in humans.
The Full Story
In 1983, researchers identified the chromosomal location associated with Huntington's disease on chromosome 4. This was a landmark in human genetics because it showed that a hereditary disease gene could be mapped even before the DNA sequence was known. It helped launch the field of positional cloning. The work ultimately led to the discovery of the huntingtin gene in 1993.
Key Facts
1.Chromosome 4 linkage identified in 1983
2.Huntington's gene later identified in 1993
3.A key step in positional cloning
YouTube Angle
Suggested video title for this topic:
"The first big breakthrough in finding disease genes"
Was this answer helpful?
Tap a reaction — it helps us pick what to cover next.