📖 what
What is X-inactivation?
Quick Answer
X-inactivation is the process by which one of the two X chromosomes in female mammals is largely silenced. It balances gene dosage between XX and XY cells.
The Full Story
In female mammals, one of the two X chromosomes in each cell is mostly turned off early in development. This process, called X-inactivation or lyonization, prevents females from producing roughly twice as much X-linked gene product as males. The inactive X becomes condensed into a structure called a Barr body. Because different cells may inactivate different X chromosomes, females can show mosaic expression for some X-linked traits.
Key Facts
1.One X chromosome is mostly silenced in XX cells
2.The inactive X forms a Barr body
3.It helps balance gene dosage between sexes
YouTube Angle
Suggested video title for this topic:
"How female cells silence one X chromosome"
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