How do live attenuated vaccines create long-lasting immunity?
Quick Answer
They use weakened versions of a germ that can still stimulate the immune system but usually do not cause illness in healthy people. Because they mimic a natural infection, they often produce strong, durable protection.
The Full Story
Live attenuated vaccines contain pathogens that have been weakened so they replicate poorly. This limited replication gives the immune system a strong training signal similar to a real infection, often producing both antibody and T-cell responses. Examples include the measles, mumps and rubella (MMR) vaccine, as well as the oral polio vaccine used in many settings. Because they are live, these vaccines are not suitable for everyone, especially people with certain immune problems.
Key Facts
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